Murray had an excellent 2015 season, winning four singles titles and reaching at least the semifinals in three of the year's four major tournaments.
Murray, who lost in his opening match at Indian Wells to qualifier Vasek Pospisil, won Miami twice in 2009 and 2013.
Defending champion Novak Djokovic joined world number one Andy Murray on the sidelines of Miami Open.
A two-time champion of the event in 2009 and 2013, Murray seized the No. 1 ranking late a year ago from Novak Djokovic, who reportedly could also miss the event because of an elbow issue. "The focus is on getting ready for the clay-court season".
Not only are the world's top two men missing from the Miami event, the biggest name in the women's game, Serena Williams, will miss the Florida tournament with the knee trouble that also caused her to opt out of Indian Wells.More news: Wisconsin teen invites former MSU running back Le'Veon Bell to prom
Murray pulled out Saturday with an elbow injury.
Murray has surpassed him as world number one and will hold an advantage of more than 4,000 ranking points over his rival come the end of the Miami Open where the victor gets 1,000.
The 2017 Miami Open runs from March 20 until April 2 at the Crandon Park Tennis Center in Miami.
Djokovic described it as "shocking" that he would have to miss the Miami event, which was set to start this week, where he won his first Masters event before making his ascent towards the top of the world rankings.