Heung-Min Son heads the first goalscorer betting in Kane's absence and is 20/1 for another hat-trick, while Manolo Gabbiadini is rated the visitors' main threat at 13/2 to net first.
"So it is a must-win game for them, but I think they will do a job without him for one, two or three games".
They held on to extend their record winning run at home to 10 Premier League matches and Pochettino said: "It's fantastic".
The exceptions are Toby Alderweireld, signed in July 2015, and Victor Wanyama, who joined in June.
The former Tottenham defender was pleased with the performance of Janssen against Southampton at White Hart Lane on Sunday.
Son has scored seven goals in 24 Premier League appearances this season, while Janssen has managed just one in 20 - although the vast majority of those have come off the bench.
"That is private but after the day off Monday he arrived with a problem with his ankle and could not train during the week", Pochettino said.
"It's his second spell on the sidelines this season and others will need to step up if they're to maintain any sort of a challenge to Chelsea at the top".More news: Sen. Gardner Says We Need A Westerner On The Supreme Court
The success of Alderweireld and Wanyama should not have come as a surprise. "Sometimes it happens that you fit quickly with a team: in a group, in a squad".
It's also worth mentioning that, although they generally have a high level of quality from back to front, the Saints' central defence is extremely vulnerable. Southampton felt that they should have had a penalty of their own at the end of the first period, after Ben Davies swung and connected with Tadic's shin. It's a good thing for them and congratulations to them and to the club. "We did not find a clinical edge to finish the situation".
Tottenham proved they were more than able to cope without star striker Harry Kane as they strengthened their grip on second place against Southampton.
After the interval, Eriksen was wayward as Spurs looked to continue very much where they had left off.
Signing more players from Southampton won't be easy.
- The only previous top-flight season than Spurs have remained unbeaten at home was 1964-1965 (21 games, 0 defeats).
"Sometimes that is the situation: you can not compete with another club". However, the Spurs' coach Mauricio Pochettino believes that this time things will be different with Kane being on the side.